Blood levels and DA transporter occupancy of orally administered methylphenidate in juvenile rhesus monkeys measured by high resolution PET.
نویسندگان
چکیده
KRISTIN M. WILCOX, YUN ZHOU, DEAN F. WONG, MOHAB ALEXANDER, ARMAN RAHMIM, JOHN HILTON, AND MICHAEL R. WEED Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore 21205 Department of Environmental Health Sciences, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205 Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
منابع مشابه
In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys.
Dopaminergic mechanisms are thought to play a central role in the reinforcing effects of cocaine. Similar to cocaine, other local anesthetics bind to the dopamine transporter (DAT) and inhibit DA uptake in rodent and monkey brain. Additionally, local anesthetics are self-administered in rhesus monkeys, indicative of abuse liability. The present study examined the reinforcing and DAT effects of ...
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ورودعنوان ژورنال:
- Synapse
دوره 62 12 شماره
صفحات -
تاریخ انتشار 2008